GHITM

The pattern of Ghitm expression suggested that once Ghitm mRNA was expressed in the putative brain region of mouse embryo, Ghitm-expressing cells spread ubiquitously throughout all tissues during embryonic development.

Full Name

growth hormone inducible transmembrane protein

Function

Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.

Biological Process

Apoptotic process Source: UniProtKB-KW
Inner mitochondrial membrane organization Source: FlyBase
Negative regulation of release of cytochrome c from mitochondria Source: FlyBase
Positive regulation of mitochondrial ATP synthesis coupled electron transport Source: FlyBase

Cellular Location

Mitochondrion inner membrane

Topology

Mitochondrial matrix: 46-82
Helical: 83-103
Mitochondrial intermembrane: 104-125
Helical: 126-146
Mitochondrial matrix: 147-159
Helical: 160-180
Mitochondrial intermembrane: 181-190
Helical: 191-211
Mitochondrial matrix: 212-213
Helical: 214-234
Mitochondrial intermembrane: 235-244
Helical: 245-265
Mitochondrial matrix: 266-271
Helical: 272-292
Mitochondrial intermembrane: 293-345