GRK4

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq]
Full Name
G protein-coupled receptor kinase 4
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Biological Process
G protein-coupled receptor internalization Source: Ensembl
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of rhodopsin mediated signaling pathway Source: Reactome
Regulation of signal transduction Source: GO_Central
Signal transduction Source: InterPro
Cellular Location
Cytoplasm; Cell cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
PTM
Palmitoylated.
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Anti-GRK4 antibodies

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Mouse Anti-GRK4 Recombinant Antibody (CBLG1-1784) (CBMAB-G5005-LY)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1784
Application*: WB
Datasheet SDS

Mouse Anti-GRK4 Recombinant Antibody (CBLG1-2968) (CBMAB-G5004-LY)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-2968
Application*: E, IP, IF, WB, P
Datasheet SDS

Mouse Anti-GRK4 Recombinant Antibody (2C5) (CBMAB-G4997-LY)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2C5
Application*: WB, E
Datasheet SDS

Mouse Anti-GRK4 Recombinant Antibody (CBLG1-2967) (V2LY-0226-LY1334)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-2967
Application*: E, IP, IF, WB, P
Datasheet SDS

Mouse Anti-GRK4 Recombinant Antibody (6D5) (V2LY-0226-LY1333)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 6D5
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-GRK4 Recombinant Antibody (CBFYH-0486) (V2LY-0226-LY1331)

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Target: GRK4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0486
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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