GSTA3

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Full Name

Glutathione S-Transferase Alpha 3

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta5-androstene-3,17-dione and delta5-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).

Biological Process

Glutathione metabolic process Source: UniProtKB
Lipid metabolic process Source: UniProtKB-KW
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Cytoplasm

Anti-GSTA3 antibodies

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Mouse Anti-GSTA3 Recombinant Antibody (CAP869) (CBMAB-AP2643LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP869

Application*: ICC, IHC, IP, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2011) (CBMAB-G5470-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBLG1-2011

Application*: WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2010) (CBMAB-G5469-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-2010

Application*: E, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2009) (CBMAB-G5468-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2009

Application*: E, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2008) (CBMAB-G5467-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2008

Application*: E

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2007) (CBMAB-G5466-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-2007

Application*: E, P, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2005) (CBMAB-G5464-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-2005

Application*: E, P, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2004) (CBMAB-G5463-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2004

Application*: E, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2003) (CBMAB-G5462-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2003

Application*: E, P, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-2002) (CBMAB-G5461-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2002

Application*: WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBLG1-262) (CBMAB-G0891-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-262

Application*: E, IC, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (1F11) (CBMAB-G0890-LY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F11

Application*: E, IH, WB

Datasheet SDS

Mouse Anti-GSTA3 Recombinant Antibody (CBFYH-0519) (CBMAB-H1395-FY)

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Target: GSTA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-0519

Application*: E, P, WB

Datasheet SDS

GSTA3 Matched Antibody Pair (507) (APMAB-507LY)

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Target: GSTA3

Specificity: Human

Datasheet SDS

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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