GSTZ1

This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
Full Name
Glutathione S-Transferase Zeta 1
Function
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
Biological Process
Glutathione metabolic process Source: UniProtKB
L-phenylalanine catabolic process Source: GO_Central
Tyrosine catabolic process Source: UniProtKB-KW
Cellular Location
Cytoplasm
Involvement in disease
Maleylacetoacetate isomerase deficiency (MAAID):
An autosomal recessive inborn error of metabolism characterized by mild elevations in succinylacetone in blood and urine, usually identified by newborn screening. Liver function and coagulation are normal. MAAID is a benign disorder.
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Anti-GSTZ1 antibodies

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Rabbit Anti-GSTZ1 Recombinant Antibody (CBLG1-2082) (CBMAB-G5631-LY)

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Target: GSTZ1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2082
Application*: E
Datasheet SDS

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2081) (CBMAB-G5630-LY)

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Target: GSTZ1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2081
Application*: E
Datasheet SDS

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2080) (CBMAB-G5629-LY)

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Target: GSTZ1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2080
Application*: WB
Datasheet SDS

Mouse Anti-GSTZ1 Recombinant Antibody (24E9.G9.G8) (CBMAB-G5627-LY)

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Target: GSTZ1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 24E9.G9.G8
Application*: WB
Datasheet SDS

Mouse Anti-GSTZ1 Recombinant Antibody (1G12) (CBMAB-G5626-LY)

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Target: GSTZ1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G12
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-272) (CBMAB-G0918-LY)

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Target: GSTZ1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-272
Application*: E, IC, WB
Datasheet SDS

GSTZ1 Matched Antibody Pair (514) (APMAB-514LY)

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Target: GSTZ1
Specificity: Human
Datasheet SDS

GSTZ1 Matched Antibody Pair (513) (APMAB-513LY)

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Target: GSTZ1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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