Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2081) (V2LY-0226-LY1927)

Name: Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2081)
SKU: V2LY-0226-LY1927
Rating: 5 (1 reviews)

See all GSTZ1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-2081

Application

Immunogen

Full length human recombinant protein of human GSTZ1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA, glycerol

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glutathione S-Transferase Zeta 1

Entrez Gene ID

2954

UniProt ID

O43708

Function

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.

Biological Process

Glutathione metabolic process Source: UniProtKB
L-phenylalanine catabolic process Source: GO_Central
Tyrosine catabolic process Source: UniProtKB-KW

Cellular Location

Cytoplasm

Involvement in disease

Maleylacetoacetate isomerase deficiency (MAAID):
An autosomal recessive inborn error of metabolism characterized by mild elevations in succinylacetone in blood and urine, usually identified by newborn screening. Liver function and coagulation are normal. MAAID is a benign disorder.

Liao, Y., Chin Chan, S., Welsh, E. A., Fang, B., Sun, L., Schönbrunn, E., ... & Rix, U. (2023). Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS Chemical Biology.

Wang, Q., Bin, C., Xue, Q., Gao, Q., Huang, A., Wang, K., & Tang, N. (2021). GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell death & disease, 12(5), 426.

Alaidaroos, N. Y., Alraies, A., Waddington, R. J., Sloan, A. J., & Moseley, R. (2021). Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence. Stem Cell Research & Therapy, 12(1), 1-19.

Lei, C., Wang, Q., Tang, N., & Wang, K. (2020). GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells. FEBS Open bio, 10(1), 6-17.

Li, J., Wang, Q., Yang, Y., Lei, C., Yang, F., Liang, L., ... & Tang, N. (2019). GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-17.

Yang, F., Li, J., Deng, H., Wang, Y., Lei, C., Wang, Q., ... & Tang, N. (2019). GSTZ 1‐1 Deficiency Activates NRF 2/IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. The EMBO Journal, 38(15), e101964.

Yang, P., Cao, W. C., Zhou, B., Zheng, T. Z., Deng, Y. L., Luo, Q., ... & Lu, W. Q. (2019). Urinary biomarker of prenatal exposure to disinfection byproducts, maternal genetic polymorphisms in CYP2E1 and GSTZ1, and birth outcomes. Environmental Science & Technology, 53(20), 12026-12034.

Tian, D. D., Bennett, S. K., Coupland, L. A., Forwood, K., Lwin, Y., Pooryousef, N., ... & Blackburn, A. C. (2019). GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. Pharmacology research & perspectives, 7(6), e00526.

Langaee, T., Wagner, R., Horne, L. P., Lawson, L. A., Becker, C., Shahin, M., ... & Stacpoole, P. W. (2018). Personalized dosing of dichloroacetate using GSTZ1 clinical genotyping assay. Genetic testing and molecular biomarkers, 22(4), 266-269.

Zhou, B., Yang, P., Gong, Y. J., Zeng, Q., Lu, W. Q., & Miao, X. P. (2018). Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes. Environmental Pollution, 243, 1126-1133.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2081)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GSTZ1 Matched Antibody Pair (513) (CAT#: APMAB-513LY)

GSTZ1 Matched Antibody Pair (514) (CAT#: APMAB-514LY)

Related Products

GSTZ1 Matched Antibody Pair (514) (CAT#: APMAB-514LY)

Rabbit Anti-GSTZ1 Recombinant Antibody (CBLG1-2082) (CAT#: V2LY-0226-LY1928)

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-272) (CAT#: V2LY-0226-LY1923)

Mouse Anti-GSTZ1 Recombinant Antibody (G8) (CAT#: CBMAB-G5627-LY)

GSTZ1 Matched Antibody Pair (513) (CAT#: APMAB-513LY)

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-3217) (CAT#: V2LY-0226-LY1919)

Mouse Anti-GSTZ1 Recombinant Antibody (1G12) (CAT#: CBMAB-G5626-LY)

Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-2080) (CAT#: V2LY-0226-LY1926)

Human Recombinant GSTZ1 protein, His Tag (CAT#: V2LY-0526-LY4439)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry