Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

GSTZ1 Matched Antibody Pair (513) (APMAB-513LY)


See all GSTZ1 antibodies
Online Inquiry

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-GSTZ1 polyclonal antibody, 100 ug
Detection Antibody
Anti-GSTZ1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
Alternative Names
Glutathione S-Transferase Zeta 1; Glutathione Transferase Zeta 1; Maleylacetoacetate Isomerase; GSTZ1-1; MAAI; S-(Hydroxyalkyl)Glutathione Lyase; Glutathione S-Aralkyltransferase; Glutathione S-Alkyltransferase;
Entrez Gene ID
2954
UniProt ID
O43708
More Infomation

Liao, Y., Chin Chan, S., Welsh, E. A., Fang, B., Sun, L., Schönbrunn, E., ... & Rix, U. (2023). Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS Chemical Biology.

Wang, Q., Bin, C., Xue, Q., Gao, Q., Huang, A., Wang, K., & Tang, N. (2021). GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell death & disease, 12(5), 426.

Alaidaroos, N. Y., Alraies, A., Waddington, R. J., Sloan, A. J., & Moseley, R. (2021). Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence. Stem Cell Research & Therapy, 12(1), 1-19.

Lei, C., Wang, Q., Tang, N., & Wang, K. (2020). GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells. FEBS Open bio, 10(1), 6-17.

Li, J., Wang, Q., Yang, Y., Lei, C., Yang, F., Liang, L., ... & Tang, N. (2019). GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-17.

Yang, F., Li, J., Deng, H., Wang, Y., Lei, C., Wang, Q., ... & Tang, N. (2019). GSTZ 1‐1 Deficiency Activates NRF 2/IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. The EMBO Journal, 38(15), e101964.

Yang, P., Cao, W. C., Zhou, B., Zheng, T. Z., Deng, Y. L., Luo, Q., ... & Lu, W. Q. (2019). Urinary biomarker of prenatal exposure to disinfection byproducts, maternal genetic polymorphisms in CYP2E1 and GSTZ1, and birth outcomes. Environmental Science & Technology, 53(20), 12026-12034.

Tian, D. D., Bennett, S. K., Coupland, L. A., Forwood, K., Lwin, Y., Pooryousef, N., ... & Blackburn, A. C. (2019). GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. Pharmacology research & perspectives, 7(6), e00526.

Langaee, T., Wagner, R., Horne, L. P., Lawson, L. A., Becker, C., Shahin, M., ... & Stacpoole, P. W. (2018). Personalized dosing of dichloroacetate using GSTZ1 clinical genotyping assay. Genetic testing and molecular biomarkers, 22(4), 266-269.

Zhou, B., Yang, P., Gong, Y. J., Zeng, Q., Lu, W. Q., & Miao, X. P. (2018). Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes. Environmental Pollution, 243, 1126-1133.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used GSTZ1 Matched Antibody Pair (513)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry