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GZMB

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Full Name
Granzyme B
Function
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927).

It cleaves after Asp (PubMed:8258716, PubMed:1985927).

Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257).

Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed:9852092).
Biological Process
Apoptotic process Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Granzyme-mediated programmed cell death signaling pathway Source: UniProtKB
Natural killer cell mediated cytotoxicity Source: UniProtKB
Negative regulation of translation Source: CACAO
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Pyroptosis Source: UniProtKB
Cellular Location
Cytolytic granule; Secreted. Delivered into the target cell by perforin (PubMed:20038786).

Anti-GZMB antibodies

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Mouse Anti-GZMB Recombinant Antibody (CBLG1-2226) (CBMAB-G5952-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2226
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2219) (CBMAB-G5945-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2219
Application*: IF, IH, IP, WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2214) (CBMAB-G5940-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2214
Application*: P

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2213) (CBMAB-G5939-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2213
Application*: C, P, WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2212) (CBMAB-G5938-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2212
Application*: F

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2211) (CBMAB-G5937-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-2211
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2210) (CBMAB-G5936-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2210
Application*: IH, IP, WB

Rabbit Anti-GZMB Recombinant Antibody (CBLG1-2209) (CBMAB-G5935-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2209
Application*: E, WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2208) (CBMAB-G5934-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2208
Application*: E

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2207) (CBMAB-G5933-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2207
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-2205) (CBMAB-G5931-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBLG1-2205
Application*: WB

Rat Anti-GZMB Recombinant Antibody (RM0338-14G13) (CBMAB-G5930-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0338-14G13
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (O2C5/F5) (CBMAB-G5928-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: O2C5/F5
Application*: IP, WB

Rabbit Anti-GZMB Recombinant Antibody (CBLG1-3058) (CBMAB-G5925-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3058
Application*: IP, P, IC/IF

Mouse Anti-GZMB Recombinant Antibody (8L90) (CBMAB-G5923-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8L90
Application*: IH, WB

Mouse Anti-GZMB Recombinant Antibody (4F5) (CBMAB-G5920-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F5
Application*: E, IP, WB

Mouse Anti-GZMB Recombinant Antibody (4E6) (CBMAB-G5918-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E6
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (4E4) (CBMAB-G5917-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E4
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (3H2182) (CBMAB-G5916-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 3H2182
Application*: E, F

Mouse Anti-GZMB Recombinant Antibody (2F5F2D10) (CBMAB-G5915-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F5F2D10
Application*: E, P

Rabbit Anti-GZMB Recombinant Antibody (23H8L20) (CBMAB-G5914-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 23H8L20
Application*: F

Rabbit Anti-GZMB Recombinant Antibody (2) (CBMAB-G5913-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2
Application*: E, P

Rat Anti-GZMB Recombinant Antibody (14G13) (CBMAB-G5911-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14G13
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (11F1) (CBMAB-G5910-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11F1
Application*: P

Mouse Anti-GZMB Recombinant Antibody (1.VB.2) (CBMAB-G5909-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.VB.2
Application*: F

Mouse Anti-GZMB Recombinant Antibody (CBLG1-295) (CBMAB-G1012-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-295
Application*: E, F

Mouse Anti-GZMB Recombinant Antibody (CBLG1-294) (CBMAB-G1011-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-294
Application*: IH, WB

Mouse Anti-GZMB Recombinant Antibody (CBLG1-293) (CBMAB-G1010-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-293
Application*: E

Human Anti-GZMB Recombinant Antibody (REA226) (CBMAB-G1009-LY)

Datasheet SDS
Target: GZMB
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: REA226
Application*: F

Mouse Anti-GZMB Recombinant Antibody (O94E6/GZMB) (CBMAB-G1008-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: O94E6/GZMB
Application*: WB

Rat Anti-GZMB Recombinant Antibody (NGZB) (CBMAB-G1007-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: NGZB
Application*: F

Rat Anti-GZMB Recombinant Antibody (LUEE) (CBMAB-G1006-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: LUEE
Application*: E

Mouse Anti-GZMB Recombinant Antibody (GZB01) (CBMAB-G1005-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GZB01
Application*: P

Mouse Anti-GZMB Recombinant Antibody (GB12) (CBMAB-G1002-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GB12
Application*: F

Mouse Anti-GZMB Recombinant Antibody (GB11) (CBMAB-G1001-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GB11
Application*: F

Mouse Anti-GZMB Recombinant Antibody (GB10) (CBMAB-G1000-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GB10
Application*: E

Rat Anti-GZMB Recombinant Antibody (eBioLUEE) (CBMAB-G0999-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: eBioLUEE
Application*: E

Mouse Anti-GZMB Recombinant Antibody (B18.1) (CBMAB-G0997-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B18.1
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (6D54) (CBMAB-G0996-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: 6D54
Application*: F

Rat Anti-GZMB Recombinant Antibody (496B) (CBMAB-G0995-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human
Clone: 496B
Application*: IC, IF, P

Mouse Anti-GZMB Recombinant Antibody (3H2181) (CBMAB-G0994-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 3H2181
Application*: E

Mouse Anti-GZMB Recombinant Antibody (351927) (CBMAB-G0993-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 351927
Application*: F

Mouse Anti-GZMB Recombinant Antibody (2C5/F5) (CBMAB-G0992-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 2C5/F5
Application*: WB

Rat Anti-GZMB Recombinant Antibody (216315) (CBMAB-G0991-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 216315
Application*: WB

Rabbit Anti-GZMB Recombinant Antibody (2103A) (CBMAB-G0990-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2103A
Application*: WB

Rat Anti-GZMB Recombinant Antibody (16G6) (CBMAB-G0989-LY)

Datasheet SDS
Target: GZMB
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 16G6
Application*: F

Mouse Anti-GZMB Recombinant Antibody (12F9B65) (CBMAB-G0988-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 12F9B65
Application*: WB

Mouse Anti-GZMB Recombinant Antibody (0.N.316) (CBMAB-G0987-LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 0.N.316
Application*: IH

Mouse Anti-GZMB Recombinant Antibody (CAP874) (CBMAB-AP2659LY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP874
Application*: IF, IHC, IP, WB

Rabbit Anti-GZMB Recombinant Antibody (CBR022E) (CBMAB-BT042LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR022E
Application*: WB, IHC, ICC, IHC-IF, mIF

Mouse Anti-GZMB Recombinant Antibody (IHC588) (CBMAB-MA108-YC)

Datasheet SDS
Target: GZMB
Host: Mouse
Specificity: Human
Clone: IHC588
Application*: IH

Rabbit Anti-GZMB Recombinant Antibody (E5V2L) (CBMAB-CP0893-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: E5V2L
Application*: WB, P, IH, F

Rabbit Anti-GZMB Recombinant Antibody (D6E9W) (CBMAB-CP0869-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D6E9W
Application*: WB, IH, P

Rabbit Anti-GZMB Recombinant Antibody (D2H2F) (CBMAB-CP0868-LY)

Datasheet SDS
Target: GZMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D2H2F
Application*: WB, IP, IF, IF (IC), F

Mouse Anti-GZMB Recombinant Antibody (CBFYH-0561) (CBMAB-H1442-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0561
Application*: E

Mouse Anti-GZMB (AA 7-227) Recombinant Antibody (CBFYH-0558) (CBMAB-H1441-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0558
Application*: IH, IP, WB

Mouse Anti-GZMB Recombinant Antibody (GrB-7) (CBMAB-H1439-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GrB-7
Application*: WB, IH, P, C

Mouse Anti-GZMB Recombinant Antibody (CBFYH-0560) (CBMAB-H0613-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0560
Application*: E, F, IH, IP

Mouse Anti-GZMB Recombinant Antibody (CBFYH-0557) (CBMAB-H0460-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0557
Application*: E, F, IH, WB

Mouse Anti-GZMB (AA 7-227) Recombinant Antibody (CBFYH-0559) (CBMAB-H0075-FY)

Datasheet SDS
Target: GZMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0559
Application*: WB, F, IF, P, C
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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