GZMM

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Full Name
Granzyme M
Function
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
T cell mediated cytotoxicity Source: Ensembl
Cellular Location
Secreted; Cytoplasmic granule. Granules of large granular lymphocytes.
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Anti-GZMM antibodies

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Mouse Anti-GZMM Recombinant Antibody (C3) (CBMAB-AP2660LY)

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Target: GZMM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C3
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-GZMM Recombinant Antibody (CBLG1-2241) (CBMAB-G5987-LY)

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Target: GZMM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2241
Application*: WB
Datasheet SDS

Mouse Anti-GZMM Recombinant Antibody (CBLG1-2239) (CBMAB-G5985-LY)

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Target: GZMM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2239
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GZMM Recombinant Antibody (4D11) (CBMAB-G5984-LY)

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Target: GZMM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D11
Application*: E, WB
Datasheet SDS

Mouse Anti-GZMM Recombinant Antibody (4B2G4) (CBMAB-G1020-LY)

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Target: GZMM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B2G4
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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