GZMM

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Granzyme M

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
T cell mediated cytotoxicity Source: Ensembl

Secreted; Cytoplasmic granule. Granules of large granular lymphocytes.