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GZMM

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Full Name

Granzyme M

Function

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Biological Process

Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
T cell mediated cytotoxicity Source: Ensembl

Cellular Location

Secreted; Cytoplasmic granule. Granules of large granular lymphocytes.

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Anti-GZMM antibodies

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Mouse Anti-GZMM Recombinant Antibody (C3) (CBMAB-AP2660LY)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: C3

Application*: WB, E, IP, IF

Mouse Anti-GZMM Recombinant Antibody (CBLG1-2241) (CBMAB-G5987-LY)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBLG1-2241

Application*: WB, E, IP, IF

Mouse Anti-GZMM Recombinant Antibody (CBLG1-2239) (CBMAB-G5985-LY)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-2239

Application*: E, WB

Mouse Anti-GZMM Recombinant Antibody (4D11) (CBMAB-G5984-LY)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4D11

Application*: WB

Mouse Anti-GZMM Recombinant Antibody (2G4) (CBMAB-G1020-LY)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G4

Application*: WB, P

Mouse Anti-GZMM Recombinant Antibody (CBLG1-2229) (V2LY-0226-LY2312)

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Target: GZMM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-2229

Application*: WB, E, IP, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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