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Mouse Anti-GZMM Recombinant Antibody (C3) (CBMAB-AP2660LY)


See all GZMM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
C3
Antibody Isotype
IgG2a, κ
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
RPA431Hu01-Recombinant Granzyme M (GZMM)
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Granzyme M
Introduction
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Entrez Gene ID
3004
UniProt ID
P51124
Alternative Names
Granzyme M; Natural Killer Cell Granular Protease; Met-1 Serine Protease; Lymphocyte Met-Ase 1; HU-Met-1; Met-Ase;
Function
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
T cell mediated cytotoxicity Source: Ensembl
Cellular Location
Secreted; Cytoplasmic granule. Granules of large granular lymphocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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