Mouse Anti-GZMM Recombinant Antibody (CBLG1-2239) (CBMAB-G5985-LY)

Name: Mouse Anti-GZMM Recombinant Antibody (CBLG1-2239)
SKU: CBMAB-G5985-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-2239

Application

S-ELISA, ELISA, WB

Immunogen

GZMM (NP_005308, 85 a.a. ~ 193 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Granzyme M

Introduction

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Entrez Gene ID

3004

UniProt ID

P51124

Alternative Names

Granzyme M; Natural Killer Cell Granular Protease; Met-1 Serine Protease; Lymphocyte Met-Ase 1; HU-Met-1; Met-Ase;

Function

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Biological Process

Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
T cell mediated cytotoxicity Source: Ensembl

Cellular Location

Secreted; Cytoplasmic granule. Granules of large granular lymphocytes.

Bin Hafeez, A., & Ahmad, J. (2022). Uncovering the evolutionary tail of GZMM: An NSP4 related protease. bioRxiv, 2022-06.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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