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HARS2

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.
Full Name
Histidyl-TRNA Synthetase 2, Mitochondrial
Function
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).
Biological Process
Histidyl-tRNA aminoacylation Source: WormBase
Translation Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome
Cellular Location
Mitochondrion
Involvement in disease
Perrault syndrome 2 (PRLTS2):
A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile.
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Anti-HARS2 antibodies

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Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0708) (CBMAB-H1597-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Monkey
Clone: CBFYH-0708
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0707) (CBMAB-H1596-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0707
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0706) (CBMAB-H1595-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0706
Application*: WB, IH
Datasheet SDS

Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0705) (CBMAB-H1594-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0705
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0704) (CBMAB-H1593-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0704
Application*: P, WB
Datasheet SDS

Mouse Anti-HARS2 Recombinant Antibody (CBFYH-0703) (CBMAB-H1592-FY)

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Target: HARS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBFYH-0703
Application*: WB, F, IH, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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