HECTD1

HECTD1 (HECT Domain E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIP12.

Full Name

HECT domain containing 1

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.

Biological Process

Anatomical structure development Source: GO_Central
Aorta development Source: BHF-UCL
Heart valve development Source: BHF-UCL
Natural killer cell differentiation Source: Ensembl
Negative regulation of protein localization to plasma membrane Source: Ensembl
Neural tube closure Source: Ensembl
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein autoubiquitination Source: Ensembl
Protein K63-linked ubiquitination Source: GO_Central
Spongiotrophoblast differentiation Source: Ensembl
Trophoblast giant cell differentiation Source: Ensembl
Ventricular septum development Source: BHF-UCL