HK2

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
Full Name
Hexokinase 2
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880).

Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880).

Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175).
Biological Process
Apoptotic mitochondrial changes Source: MGI
Canonical glycolysis Source: Reactome
Cellular glucose homeostasis Source: GO_Central
Cellular response to leukemia inhibitory factor Source: Ensembl
Establishment of protein localization to mitochondrion Source: ParkinsonsUK-UCL
Fructose 6-phosphate metabolic process Source: UniProtKB
Glucose 6-phosphate metabolic process Source: UniProtKB
Glycolytic process Source: GO_Central
Lactation Source: Ensembl
Maintenance of protein location in mitochondrion Source: ParkinsonsUK-UCL
Negative regulation of mitochondrial membrane permeability Source: Ensembl
Negative regulation of reactive oxygen species metabolic process Source: Ensembl
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
Regulation of glucose import Source: Ensembl
Response to hypoxia Source: Ensembl
Response to ischemia Source: Ensembl
Cellular Location
Mitochondrion outer membrane; Cytosol. The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175).
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Anti-HK2 antibodies

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Mouse Anti-HK2 Recombinant Antibody (A191) (CBMAB-AP3073LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Pig, Rat
Clone: A191
Application*: ELISA, FC, WB
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (A190) (CBMAB-AP9628LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A190
Application*: FC, WB
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (A189) (CBMAB-AP2996LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Pig, Rat
Clone: A189
Application*: FC, WB
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CB407A) (CBMAB-CA407LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Mouse, Rat
Clone: CB407A
Application*: ELISA, WB, FC
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (3D3) (CBMAB-AO565LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D3
Application*: WB, IHC
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (4H1) (CBMAB-A3928-LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 4H1
Application*: WB, E
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (1E8-H3-F11) (CBMAB-Z0197-LY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse, Monkey
Clone: 1E8-H3-F11
Application*: WB
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBFYH-1236) (CBMAB-H2208-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human
Clone: CBFYH-1236
Application*: WB, E, F
Datasheet SDS

Mouse Anti-HK2 (AA 818-917) Recombinant Antibody (CBFYH-1235) (CBMAB-H2207-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1235
Application*: E, WB
Datasheet SDS

Mouse Anti-HK2 (N-terminus) Recombinant Antibody (CBFYH-1231) (CBMAB-H2204-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYH-1231
Application*: E, WB, F
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBFYH-1230) (CBMAB-H2203-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Mouse, Rat
Clone: CBFYH-1230
Application*: WB, F
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBFYH-1228) (CBMAB-H2201-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1228
Application*: WB
Datasheet SDS

Mouse Anti-HK2 (AA 11-917) Recombinant Antibody (CBFYH-1225) (CBMAB-H2200-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1225
Application*: WB, IH
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBFYH-1224) (CBMAB-H2199-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1224
Application*: E, F, IH, WB
Datasheet SDS

Rabbit Anti-HK2 Recombinant Antibody (H.738.7) (CBMAB-H2198-FY)

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Target: HK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: H.738.7
Application*: IC, IF, P, WB
Datasheet SDS

Rabbit Anti-HK2 Recombinant Antibody (C64G5) (CBMAB-H2197-FY)

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Target: HK2
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: C64G5
Application*: WB
Datasheet SDS

Rabbit Anti-HK2 (AA 325-444) Recombinant Antibody (2H8L6) (CBMAB-H2196-FY)

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Target: HK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2H8L6
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-HK2 Monoclonal Antibody (CBFYH-3091) (CBMAB-H2195-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human, Pig
Clone: CBFYH-3091
Application*: WB, E, F
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBFYH-1232) (CBMAB-H0795-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBFYH-1232
Application*: WB, P, PE
Datasheet SDS

Mouse Anti-HK2 (AA 1-917) Recombinant Antibody (CBFYH-1226) (CBMAB-H0378-FY)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1226
Application*: WB, E
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBT760) (V2LY-0625-LY3300)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT760
Application*: WB, P, IF, F, E
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBT761) (V2LY-0625-LY3299)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Pig
Clone: CBT761
Application*: WB
Datasheet SDS

Mouse Anti-HK2 Recombinant Antibody (CBT2955) (V2LY-0625-LY2446)

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Target: HK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2955
Application*: WB, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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