HSD17B12

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM

Full Name

hydroxysteroid (17-beta) dehydrogenase 12

Function

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Biological Process

Estrogen biosynthetic process Source: UniProtKB-UniPathway
Extracellular matrix organization Source: Ensembl
Fatty acid biosynthetic process Source: UniProtKB-UniPathway
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cell-substrate adhesion Source: Ensembl

Cellular Location

Endoplasmic reticulum membrane