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Mouse Anti-HSD17B12 Recombinant Antibody (CBFYH-2004) (CBMAB-H0728-FY)

This product is mouse antibody that recognizes HSD17B12. The antibody CBFYH-2004 can be used for immunoassay techniques such as: ELISA, WB.
See all HSD17B12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2004
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 12
Introduction
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.
Entrez Gene ID
51144
UniProt ID
Q53GQ0
Alternative Names
Hydroxysteroid 17-Beta Dehydrogenase 12; 3-Ketoacyl-CoA Reductase; Short Chain Dehydrogenase/Reductase Family 12C Member 1; 17-Beta-Hydroxysteroid Dehydrogenase 12; Estradiol 17-Beta-Dehydrogenase 12; 17-Beta-HSD 12; SDR12C1; KAR
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Biological Process
Estrogen biosynthetic process Source: UniProtKB-UniPathway
Extracellular matrix organization Source: Ensembl
Fatty acid biosynthetic process Source: UniProtKB-UniPathway
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cell-substrate adhesion Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane

Ichida, H., Fukami, T., Kudo, T., Mishiro, K., Takano, S., Nakano, M., ... & Nakajima, M. (2023). Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism. Archives of Biochemistry and Biophysics, 736, 109536.

Liu, H., Li, G., Sturgis, E. M., Shete, S., Dahlstrom, K. R., Du, M., ... & Wei, Q. (2022). Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. International journal of cancer, 151(4), 553-564.

Juengel, J. L., Mosaad, E. M. O., Mitchell, M. D., Phyn, C. V. C., French, M. C., Meenken, E. D., ... & Meier, S. (2022). Relationships between prostaglandin concentrations, a single nucleotide polymorphism in HSD17B12, and reproductive performance in dairy cows. Journal of Dairy Science, 105(5), 4643-4652.

Wang, Q., Chen, Q., Zhang, Y., Zhang, X., Liu, C., Wang, D., ... & Zhang, F. (2022). HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice. Clinical and Translational Medicine, 12(2), e737.

Lin, Y., Meng, Y., Zhang, J., Ma, L., Jiang, L., Zhang, Y., ... & Zhu, L. (2020). Functional genetic variant of HSD17B12 in the fatty acid biosynthesis pathway predicts the outcome of colorectal cancer. Journal of Cellular and Molecular Medicine, 24(24), 14160-14170.

Mohamed, B., Mazeaud, C., Baril, M., Poirier, D., Sow, A. A., Chatel-Chaix, L., ... & Lamarre, D. (2020). Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses. Scientific Reports, 10(1), 4040.

Hachim, M. Y., Aljaibeji, H., Hamoudi, R. A., Hachim, I. Y., Elemam, N. M., Mohammed, A. K., ... & Sulaiman, N. (2020). An integrative phenotype–genotype approach using phenotypic characteristics from the UAE national diabetes study identifies HSD17B12 as a candidate gene for obesity and type 2 diabetes. Genes, 11(4), 461.

Dai, W., Liu, H., Xu, X., Ge, J., Luo, S., Zhu, D., ... & Wei, Q. (2019). Genetic variants in ELOVL2 and HSD17B12 predict melanoma‐specific survival. International journal of cancer, 145(10), 2619-2628.

Kemiläinen, H., Huhtinen, K., Auranen, A., Carpén, O., Strauss, L., & Poutanen, M. (2018). The expression of HSD17B12 is associated with COX-2 expression and is increased in high-grade epithelial ovarian cancer. Oncology, 94(4), 233-242.

Yang, Y., Fang, X., Yang, R., Yu, H., Jiang, P., Sun, B., & Zhao, Z. (2018). MiR-152 regulates apoptosis and triglyceride production in MECs via targeting ACAA2 and HSD17B12 genes. Scientific Reports, 8(1), 417.

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For research use only. Not intended for any clinical use.

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