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HTRA2

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Full Name
HtrA Serine Peptidase 2
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Biological Process
Adult walking behavior Source: Ensembl
Aging Source: Ensembl
Cellular protein catabolic process Source: ParkinsonsUK-UCL
Cellular response to growth factor stimulus Source: UniProtKB
Cellular response to heat Source: UniProtKB
Cellular response to interferon-beta Source: ParkinsonsUK-UCL
Cellular response to oxidative stress Source: ParkinsonsUK-UCL
Cellular response to retinoic acid Source: ParkinsonsUK-UCL
Ceramide metabolic process Source: Ensembl
Execution phase of apoptosis Source: UniProtKB
Forebrain development Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: ParkinsonsUK-UCL
Mitochondrion organization Source: Ensembl
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Negative regulation of neuron death Source: ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Neuron development Source: Ensembl
Pentacyclic triterpenoid metabolic process Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
Positive regulation of mitochondrion organization Source: ParkinsonsUK-UCL
Positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Programmed cell death Source: UniProtKB
Protein autoprocessing Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of multicellular organism growth Source: Ensembl
Response to herbicide Source: Ensembl
Cellular Location
Mitochondrion intermembrane space; Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Isoform 1: Endoplasmic reticulum
Involvement in disease
3-methylglutaconic aciduria 8 (MGCA8):
An autosomal recessive inborn error of metabolism resulting in early death. Clinical features include extreme hypertonia observed at birth, alternating with hypotonia, subsequent appearance of extrapyramidal symptoms, lack of psychomotor development, microcephaly, and intractable seizures. Patients show lactic acidemia, 3-methylglutaconic aciduria, intermittent neutropenia, and progressive brain atrophy.
Parkinson disease 13 (PARK13):
A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Topology
Helical: 105-125
PTM
Autoproteolytically activated.

Anti-HTRA2 antibodies

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Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G5
Application*: WB, E
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2526
Application*: E, EC, IF, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2525
Application*: IF, WB, IH
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2524
Application*: E
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2523
Application*: E, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2522
Application*: E, IF, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2519
Application*: E, IF, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2518
Application*: P, IP, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2517
Application*: E, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2513
Application*: E, IF, WB
Target: HTRA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-2509
Application*: WB, P, IP
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2508
Application*: E, WB
Target: HTRA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D20A5
Application*: WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AT3F9
Application*: E, WB, IC, IF
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3267
Application*: WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Hamster
Clone: CBFYH-3266
Application*: WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2515
Application*: E, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2514
Application*: E, IC, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2511
Application*: WB, F, E, IF
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYH-2512
Application*: WB, E
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3265
Application*: WB, IH, P
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0289
Application*: E
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0478
Application*: IH, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F9
Application*: E, F, IC, IF, WB
Target: HTRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1B3
Application*: WB, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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