IGFBP6

IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Exfoliative Ichthyosis. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.
Full Name
insulin-like growth factor binding protein 6
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).
Biological Process
Cell migration Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of stress-activated MAPK cascade Source: UniProtKB
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.
View more

Anti-IGFBP6 antibodies

+ Filters
Loading...

Mouse Anti-IGFBP6 Recombinant Antibody (CBYY-I1437) (CBMAB-I2607-YY)

Go to compareCompare
Target: IGFBP6
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1437
Application*: N, WB
Datasheet SDS

Mouse Anti-IGFBP6 Recombinant Antibody (CBYY-I1299) (CBMAB-I2468-YY)

Go to compareCompare
Target: IGFBP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1299
Application*: E
Datasheet SDS

Rat Anti-IGFBP6 Recombinant Antibody (21D24) (CBMAB-I0152-YY)

Go to compareCompare
Target: IGFBP6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 21D24
Application*: WB
Datasheet SDS

Mouse Anti-IGFBP6 Recombinant Antibody (1.A.19) (CBMAB-I0150-YY)

Go to compareCompare
Target: IGFBP6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1.A.19
Application*: E
Datasheet SDS

Human IGFBP6 ELISA Kit (V2LY-0626-LY3902)

Go to compareCompare
Target: IGFBP6
Sensitivity: 0.17 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Igfbp6 ELISA Kit (V2LY-0626-LY2389)

Go to compareCompare
Target: Igfbp6
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Recombinant IGFBP6 protein, His Tag (V2LY-0526-LY8442)

Go to compareCompare
Target: IGFBP6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-238
Tag: His Tag
Datasheet SDS

Rat Recombinant IGFBP6 protein, His Tag (V2LY-0526-LY9430)

Go to compareCompare
Target: IGFBP6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: His Tag
Datasheet SDS

Human Recombinant IGFBP6 protein, His Tag (V2LY-0526-LY4672)

Go to compareCompare
Target: IGFBP6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-240
Tag: His Tag
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.