IGFBP6

IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Exfoliative Ichthyosis. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

Full Name

insulin-like growth factor binding protein 6

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).

Biological Process

Cell migration Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of stress-activated MAPK cascade Source: UniProtKB
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.