Sign in or Register   Sign in or Register
  |  

Mouse Anti-IGFBP6 Recombinant Antibody (1.A.19) (CBMAB-I0150-YY)

This product is Mouse antibody that recognizes IGFBP6. The antibody 1.A.19 can be used for immunoassay techniques such as: ELISA
See all IGFBP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1.A.19
Antibody Isotype
IgG
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1M Tris HCl, pH 7.5
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
insulin-like growth factor binding protein 6
Introduction
IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Exfoliative Ichthyosis. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.
Entrez Gene ID
3489
UniProt ID
P24592
Alternative Names
Insulin Like Growth Factor Binding Protein 6
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).
Biological Process
Cell migration Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of stress-activated MAPK cascade Source: UniProtKB
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.

Venuto, S., Coda, A. R. D., González-Pérez, R., Laselva, O., Tolomeo, D., Storlazzi, C. T., ... & Conese, M. (2023). IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression. International Journal of Molecular Sciences, 24(5), 4804.

Longhitano, L., Vicario, N., Forte, S., Giallongo, C., Broggi, G., Caltabiano, R., ... & Tibullo, D. (2023). Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Cancer Immunology, Immunotherapy, 72(1), 1-20.

Liso, A., Venuto, S., Coda, A. R. D., Giallongo, C., Palumbo, G. A., & Tibullo, D. (2022). IGFBP-6: at the crossroads of immunity, tissue repair and fibrosis. International Journal of Molecular Sciences, 23(8), 4358.

Laselva, O., Criscione, M. L., Allegretta, C., Di Gioia, S., Liso, A., & Conese, M. (2022). Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells. Frontiers in Molecular Biosciences, 9, 905468.

Longhitano, L., Forte, S., Orlando, L., Grasso, S., Barbato, A., Vicario, N., ... & Tibullo, D. (2022). The crosstalk between GPR81/IGFBP6 promotes breast cancer progression by modulating lactate metabolism and oxidative stress. Antioxidants, 11(2), 275.

Longhitano, L., Tibullo, D., Vicario, N., Giallongo, C., La Spina, E., Romano, A., ... & Liso, A. (2021). IGFBP-6/sonic hedgehog/TLR4 signalling axis drives bone marrow fibrotic transformation in primary myelofibrosis. Aging (Albany NY), 13(23), 25055.

Liu, Y., Huan, W., Wu, J., Zou, S., & Qu, L. (2020). IGFBP6 is downregulated in unstable carotid atherosclerotic plaques according to an integrated bioinformatics analysis and experimental verification. Journal of Atherosclerosis and Thrombosis, 27(10), 1068-1085.

Shkurnikov, M., Nikulin, S., Nersisyan, S., Poloznikov, A., Zaidi, S., Baranova, A., ... & Tonevitsky, A. (2019). LAMA4-regulating miR-4274 and its host gene SORCS2 play a role in IGFBP6-dependent effects on phenotype of basal-like breast cancer. Frontiers in molecular biosciences, 6, 122.

Conese, M., D’Oria, S., Castellani, S., Trotta, R., Montemurro, P., & Liso, A. (2018). Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis. Inflammation Research, 67, 107-109.

Liso, A., Capitanio, N., Gerli, R., & Conese, M. (2018). From fever to immunity: A new role for IGFBP‐6?. Journal of cellular and molecular medicine, 22(10), 4588-4596.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IGFBP6 Recombinant Antibody (1.A.19)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare