IL22RA2
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Full Name
Interleukin 22 Receptor Subunit Alpha 2
Function
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseIEA:Ensembl
Regulation of tyrosine phosphorylation of STAT proteinISS:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Regulation of tyrosine phosphorylation of STAT proteinISS:UniProtKB
Cellular Location
Secreted
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Anti-IL22RA2 antibodies
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CompareTarget: Il22ra2
Sensitivity: 0.0092 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL22RA2
Sensitivity: 0.0098 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-231
Tag: His Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: His Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-263
Tag: His Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: His & hFc Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-263
Tag: hFc Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-231
Tag: hFc Tag
Target: IL22RA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: His Tag
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A538
Application*: ELISA, IHC, WB
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF233
Application*: ELISA, WB, IHC
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1382
Application*: E
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1200
Application*: WB
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1045
Application*: E, WB, IH
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 875504
Application*: F, MC
Target: IL22RA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 214518
Application*: WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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