Human Recombinant IL22RA2 protein, His & hFc Tag (V2LY-0526-LY4844)

Name: Human Recombinant IL22RA2 protein, His & hFc Tag
SKU: V2LY-0526-LY4844
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & hFc Tag

Protein Construction

This product is Human Recombinant IL22RA2 protein, His & hFc Tag consist of Amino Acid: 1-231 and predicts a molecular mass of 52.8 kDa.

Molecule Mass

52.8 kDa

Sequence

Amino Acid: 1-231

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium citrate buffer

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 22 Receptor Subunit Alpha 2

Function

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseIEA:Ensembl
Regulation of tyrosine phosphorylation of STAT proteinISS:UniProtKB

Cellular Location

Secreted

Ke, Y., Li, B. Z., Nguyen, K., Wang, D., Wang, S., Young, C. D., & Wang, X. J. (2023). IL22RA2 is a Smad7 target mediating alleviation of dermatitis and psoriatic phenotypes in mice. Journal of Investigative Dermatology.

Gómez-Fernández, P., Lopez de Lapuente Portilla, A., Astobiza, I., Mena, J., Urtasun, A., Altmann, V., ... & Vandenbroeck, K. (2020). The rare IL22RA2 signal peptide coding variant rs28385692 decreases secretion of IL-22BP isoform-1,-2 and-3 and is associated with risk for multiple sclerosis. Cells, 9(1), 175.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL22RA2 protein, His Tag (CAT#: V2LY-0526-LY1568)

Human Recombinant IL22RA2 protein, hFc Tag (CAT#: V2LY-0526-LY4842)

Human Recombinant IL22RA2 protein, hFc Tag-1 (CAT#: V2LY-0526-LY4843)

Human Recombinant IL22RA2 protein, His Tag (CAT#: V2LY-0526-LY4845)

Human Recombinant IL22RA2 protein, His Tag-1 (CAT#: V2LY-0526-LY4846)

Human Recombinant IL22RA2 protein, His Tag-2 (CAT#: V2LY-0526-LY4847)

Human IL22RA2 ELISA Kit (CAT#: V2LY-0626-LY4764)

Mouse Il22ra2 ELISA Kit (CAT#: V2LY-0626-LY5862)

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Human Recombinant IL22RA2 protein, His Tag (CAT#: V2LY-0526-LY4845)

Human Recombinant IL22RA2 protein, His Tag-1 (CAT#: V2LY-0526-LY4846)

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Human Recombinant IL22RA2 protein, hFc Tag-1 (CAT#: V2LY-0526-LY4843)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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