Mouse Anti-IL22RA2 Recombinant Antibody (CBYY-I1382) (CBMAB-I2552-YY)

Name: Mouse Anti-IL22RA2 Recombinant Antibody (CBYY-I1382)
SKU: CBMAB-I2552-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1382

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 22 Receptor Subunit Alpha 2

Introduction

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Entrez Gene ID

116379

UniProt ID

Q969J5

Alternative Names

Interleukin 22 Receptor Subunit Alpha 2

Function

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseIEA:Ensembl
Regulation of tyrosine phosphorylation of STAT proteinISS:UniProtKB

Cellular Location

Secreted

Ke, Y., Li, B. Z., Nguyen, K., Wang, D., Wang, S., Young, C. D., & Wang, X. J. (2023). IL22RA2 is a Smad7 target mediating alleviation of dermatitis and psoriatic phenotypes in mice. Journal of Investigative Dermatology.

Gómez-Fernández, P., Lopez de Lapuente Portilla, A., Astobiza, I., Mena, J., Urtasun, A., Altmann, V., ... & Vandenbroeck, K. (2020). The rare IL22RA2 signal peptide coding variant rs28385692 decreases secretion of IL-22BP isoform-1,-2 and-3 and is associated with risk for multiple sclerosis. Cells, 9(1), 175.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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