INPP5F

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Full Name

Inositol Polyphosphate-5-Phosphatase F

Function

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).
Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).
Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).
Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).
Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).
May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

Biological Process

Adult locomotory behaviorIEA:Ensembl
Cardiac muscle hypertrophy in response to stressISS:UniProtKB
Clathrin-dependent endocytosisISS:UniProtKB
Negative regulation of axon regenerationISS:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationIEA:Ensembl
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol catabolic processISS:UniProtKB
Phosphatidylinositol dephosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Phosphatidylinositol-mediated signalingISS:UniProtKB
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase B signalingIEA:Ensembl

Cellular Location

Membrane, clathrin-coated pit; Early endosome; Recycling endosome. Also found on macropinosomes.