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Mouse Anti-INPP5F Recombinant Antibody (S166A-26) (CBMAB-I1060-YY)

This product is Mouse antibody that recognizes INPP5F. The antibody S166A-26 can be used for immunoassay techniques such as: WB, ICC, IF
See all INPP5F antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S166A-26
Antibody Isotype
IgG1
Application
WB, ICC, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inositol Polyphosphate-5-Phosphatase F
Introduction
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human22876
Mouse101490
Rat309008
UniProt ID
HumanQ9Y2H2
MouseQ8CDA1
RatD3ZKG7
Alternative Names
Inositol Polyphosphate-5-Phosphatase F
Function
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).
Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).
Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).
Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).
Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).
May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
Biological Process
Adult locomotory behaviorIEA:Ensembl
Cardiac muscle hypertrophy in response to stressISS:UniProtKB
Clathrin-dependent endocytosisISS:UniProtKB
Negative regulation of axon regenerationISS:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationIEA:Ensembl
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol catabolic processISS:UniProtKB
Phosphatidylinositol dephosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Phosphatidylinositol-mediated signalingISS:UniProtKB
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase B signalingIEA:Ensembl
Cellular Location
Membrane, clathrin-coated pit; Early endosome; Recycling endosome. Also found on macropinosomes.

Zhang, S., Chen, G., Wang, X., Tong, L., Wang, L., Liu, T., ... & Du, D. (2023). LncRNA INPP5F ameliorates stress‐induced hypertension via the miR‐335/Cttn axis in rostral ventrolateral medulla. CNS Neuroscience & Therapeutics.

Xue, F., Gao, L., Chen, T., Chen, H., Zhang, H., Wang, T., ... & Zhang, Y. (2022). Parkinson’s Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer’s Disease. Journal of Alzheimer's Disease, (Preprint), 1-11.

Zhou, Q., Lin, J., Yan, Y., Meng, S., Liao, H., Chen, R., ... & Xiao, Z. (2022). INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 41(1), 1-16.

Cao, M., Park, D., Wu, Y., & De Camilli, P. (2020). Absence of Sac2/INPP5F enhances the phenotype of a Parkinson’s disease mutation of synaptojanin 1. Proceedings of the National Academy of Sciences, 117(22), 12428-12434.

Zhao, X., Chang, S., Liu, X., Wang, S., Zhang, Y., Lu, X., ... & Wang, L. (2020). Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations. Journal of Cellular and Molecular Medicine, 24(17), 9898-9907.

Yuan, L., Liu, C., Wan, Y., Yan, H., & Li, T. (2019). Effect of HDAC2/Inpp5f on neuropathic pain and cognitive function through regulating PI3K/Akt/GSK‑3β signal pathway in rats with neuropathic pain. Experimental and Therapeutic Medicine, 18(1), 678-684.

Yuan, L., Li, T., Wan, Y., Liu, Y., Zhou, X., & Liu, C. (2019). Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain. Experimental and Therapeutic Medicine, 17(2), 1300-1305.

Nguyen, P. M., Gandasi, N. R., & Idevall-Hagren, O. (2018). The lipid phosphatase INPP5F regulates insulin secretion. In Diabetologia (Vol. 61, pp. S197-S197). Springer.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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