Mouse Anti-INPP5F Recombinant Antibody (A630) (CBMAB-AP10875LY)

Name: Mouse Anti-INPP5F Recombinant Antibody (A630)
SKU: CBMAB-AP10875LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A630

Application

ICC/IF, WB

Immunogen

Fusion protein amino acids 1-901 (full-length) of human INPP5F

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Inositol Polyphosphate-5-Phosphatase F

Introduction

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Entrez Gene ID

Human	22876
Mouse	101490
Rat	309008

UniProt ID

Human	Q9Y2H2
Mouse	Q8CDA1
Rat	D3ZKG7

Alternative Names

Inositol Polyphosphate-5-Phosphatase F

Function

SMC-464D

Biological Process

Adult locomotory behaviorIEA:Ensembl
Cardiac muscle hypertrophy in response to stressISS:UniProtKB
Clathrin-dependent endocytosisISS:UniProtKB
Negative regulation of axon regenerationISS:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationIEA:Ensembl
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol catabolic processISS:UniProtKB
Phosphatidylinositol dephosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Phosphatidylinositol-mediated signalingISS:UniProtKB
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase B signalingIEA:Ensembl

Cellular Location

Membrane, clathrin-coated pit; Early endosome; Recycling endosome. Also found on macropinosomes.

Zhang, S., Chen, G., Wang, X., Tong, L., Wang, L., Liu, T., ... & Du, D. (2023). LncRNA INPP5F ameliorates stress‐induced hypertension via the miR‐335/Cttn axis in rostral ventrolateral medulla. CNS Neuroscience & Therapeutics.

Xue, F., Gao, L., Chen, T., Chen, H., Zhang, H., Wang, T., ... & Zhang, Y. (2022). Parkinson’s Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer’s Disease. Journal of Alzheimer's Disease, (Preprint), 1-11.

Zhou, Q., Lin, J., Yan, Y., Meng, S., Liao, H., Chen, R., ... & Xiao, Z. (2022). INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 41(1), 1-16.

Cao, M., Park, D., Wu, Y., & De Camilli, P. (2020). Absence of Sac2/INPP5F enhances the phenotype of a Parkinson’s disease mutation of synaptojanin 1. Proceedings of the National Academy of Sciences, 117(22), 12428-12434.

Zhao, X., Chang, S., Liu, X., Wang, S., Zhang, Y., Lu, X., ... & Wang, L. (2020). Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations. Journal of Cellular and Molecular Medicine, 24(17), 9898-9907.

Yuan, L., Liu, C., Wan, Y., Yan, H., & Li, T. (2019). Effect of HDAC2/Inpp5f on neuropathic pain and cognitive function through regulating PI3K/Akt/GSK‑3β signal pathway in rats with neuropathic pain. Experimental and Therapeutic Medicine, 18(1), 678-684.

Yuan, L., Li, T., Wan, Y., Liu, Y., Zhou, X., & Liu, C. (2019). Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain. Experimental and Therapeutic Medicine, 17(2), 1300-1305.

Nguyen, P. M., Gandasi, N. R., & Idevall-Hagren, O. (2018). The lipid phosphatase INPP5F regulates insulin secretion. In Diabetologia (Vol. 61, pp. S197-S197). Springer.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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