INSRR

INSRR (Insulin Receptor Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include Regular Astigmatism and Podoconiosis. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is IGF1R.
Full Name
insulin receptor-related receptor
Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to alkaline pHManual Assertion Based On ExperimentIDA:UniProtKB
Male sex determinationIEA:Ensembl
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 747-921
Helical: 922-943
Cytoplasmic: 944-1297
PTM
Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
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Anti-INSRR antibodies

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Mouse Anti-INSRR Recombinant Antibody (5C6) (CBMAB-A4496-LY)

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Target: INSRR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5C6
Application*: WB, E
Datasheet SDS

Mouse Anti-INSRR Recombinant Antibody (2C1) (CBMAB-A4495-LY)

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Target: INSRR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2C1
Application*: WB, E
Datasheet SDS

Mouse Anti-INSRR Recombinant Antibody (CBYY-I1012) (CBMAB-I2180-YY)

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Target: INSRR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBYY-I1012
Application*: E, WB
Datasheet SDS

Rabbit Anti-INSRR Recombinant Antibody (CBYY-I0764) (CBMAB-I1696-YY)

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Target: INSRR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-I0764
Application*: IH, WB
Datasheet SDS

Mouse Anti-INSRR Recombinant Antibody (CBYY-I1192) (CBMAB-I2361-YY)

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Target: INSRR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1192
Application*: E, P, WB
Datasheet SDS

Rabbit Anti-INSRR Recombinant Antibody (BA0055) (CBMAB-0393CQ)

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Target: INSRR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0055
Application*: P, WB
Datasheet SDS

Mouse Anti-INSRR Recombinant Antibody (MM077125K51) (CBMAB-0392CQ)

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Target: INSRR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM077125K51
Application*: WB, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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