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Rabbit Anti-INSRR Recombinant Antibody (BA0055) (CBMAB-0393CQ)

This product is a rabbit antibody that recognizes INSRR. The antibody BA0055 can be used for immunoassay techniques such as: IHC-P, WB.
See all INSRR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0055
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide from residues near the N-terminus of human IRR alpha subunit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
insulin receptor-related receptor
Introduction
INSRR (Insulin Receptor Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include Regular Astigmatism and Podoconiosis. Among its related pathways are Akt Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is IGF1R. Using genomic DNA encoding part of IRR in Southern blot analysis of DNA from human-mouse cell hybrids, Shier et al. (1990) assigned the INSRR gene to human chromosome 1. By radiation hybrid analysis, Whitmore et al. (1999) mapped the gene to chromosome 1q21-q23. This similarity suggested that the insulin receptor-related receptor (IRR) mediates the action of a ligand that is identical or very similar to insulin (176730), IGF1 (147440), or IGF2 (147470). Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Entrez Gene ID
Human3645
Mouse23920
Rat60663
UniProt ID
HumanP14616
MouseQ9WTL4
RatQ64716
Alternative Names
IRR
Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to alkaline pHManual Assertion Based On ExperimentIDA:UniProtKB
Male sex determinationIEA:Ensembl
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 747-921
Helical: 922-943
Cytoplasmic: 944-1297
PTM
Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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