IRS2

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Full Name

Insulin Receptor Substrate 2

Function

May mediate the control of various cellular processes by insulin.

Biological Process

Brain developmentIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Insulin receptor signaling pathwayISS:BHF-UCL
Lipid homeostasisManual Assertion Based On ExperimentTAS:BHF-UCL
Mammary gland developmentIEA:Ensembl
Negative regulation of B cell apoptotic processISS:BHF-UCL
Negative regulation of kinase activityISS:BHF-UCL
Negative regulation of long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of B cell proliferationISS:BHF-UCL
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of cell population proliferation1 PublicationNAS:BHF-UCL
Positive regulation of fatty acid beta-oxidationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose importManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionISS:BHF-UCL
Positive regulation of mesenchymal cell proliferationIEA:Ensembl
Regulation of lipid metabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Response to glucoseISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm, cytosol