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Mouse Anti-IRS2 Recombinant Antibody (L55B10) (CBMAB-CP1184-LY)

The product is antibody recognizes IRS2. The antibody L55B10 immunoassay techniques such as: WB,IP.
See all IRS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
L55B10
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant human insulin receptor β carboxy-terminal fragments.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Insulin Receptor Substrate 2
Introduction
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human8660
Mouse384783
Rat29376
Monkey698536
UniProt ID
HumanQ9Y4H2
MouseP81122
RatF1MAL5
MonkeyF7DE94
Alternative Names
Insulin Receptor Substrate 2
Function
May mediate the control of various cellular processes by insulin.
Biological Process
Brain developmentIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Insulin receptor signaling pathwayISS:BHF-UCL
Lipid homeostasisManual Assertion Based On ExperimentTAS:BHF-UCL
Mammary gland developmentIEA:Ensembl
Negative regulation of B cell apoptotic processISS:BHF-UCL
Negative regulation of kinase activityISS:BHF-UCL
Negative regulation of long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of B cell proliferationISS:BHF-UCL
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of cell population proliferation1 PublicationNAS:BHF-UCL
Positive regulation of fatty acid beta-oxidationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose importManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionISS:BHF-UCL
Positive regulation of mesenchymal cell proliferationIEA:Ensembl
Regulation of lipid metabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Response to glucoseISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, cytosol

Takatani, T., Shirakawa, J., Shibue, K., Gupta, M. K., Kim, H., Lu, S., ... & Kulkarni, R. N. (2021). Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. Journal of Biological Chemistry, 296.

Ochiai, T., Sano, T., Nagayama, T., Kubota, N., Kadowaki, T., Wakabayashi, T., & Iwatsubo, T. (2021). Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiology of Disease, 159, 105510.

Neff, A. M., Yu, J., Taylor, R. N., Bagchi, I. C., & Bagchi, M. K. (2020). Insulin signaling via progesterone-regulated insulin receptor substrate 2 is critical for human uterine decidualization. Endocrinology, 161(1), bqz021.

Villar-Lorenzo, A., Rada, P., Rey, E., Marañón, P., Arroba, A. I., Santamaria, B., ... & Gonzalez-Rodriguez, A. (2019). Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury. Disease Models & Mechanisms, 12(7), dmm038810.

Iglesias-Osma, M. C., Blanco, E. J., Carretero-Hernandez, M., Catalano-Iniesta, L., Sanchez-Robledo, V., Garcia-Barrado, M. J., ... & Carretero, J. (2019). The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland. Scientific reports, 9(1), 5673.

Piper, A. J., Clark, J. L., Mercado-Matos, J., Matthew-Onabanjo, A. N., Hsieh, C. C., Akalin, A., & Shaw, L. M. (2019). Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC). PLoS One, 14(8), e0220567.

Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Kahn, C. R., & Emanuelli, B. (2018). Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. Cellular signalling, 47, 1-15.

Mercado-Matos, J., Janusis, J., Zhu, S., Chen, S. S., & Shaw, L. M. (2018). Identification of a novel invasion-promoting region in insulin receptor substrate 2. Molecular and Cellular Biology, 38(14), e00590-17.

Turaihi, A. H., Bakker, W., Van Hinsbergh, V. W., Serné, E. H., Smulders, Y. M., Niessen, H. W., & Eringa, E. C. (2018). Insulin receptor substrate 2 controls insulin-mediated vasoreactivity and perivascular adipose tissue function in muscle. Frontiers in physiology, 9, 245.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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