Mouse Irs2 ELISA Kit (V2LY-0626-LY1442)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.012 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
136.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Insulin Receptor Substrate 2
Function
May mediate the control of various cellular processes by insulin.
Biological Process
Brain developmentIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Insulin receptor signaling pathwayISS:BHF-UCL
Lipid homeostasisManual Assertion Based On ExperimentTAS:BHF-UCL
Mammary gland developmentIEA:Ensembl
Negative regulation of B cell apoptotic processISS:BHF-UCL
Negative regulation of kinase activityISS:BHF-UCL
Negative regulation of long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of B cell proliferationISS:BHF-UCL
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of cell population proliferation1 PublicationNAS:BHF-UCL
Positive regulation of fatty acid beta-oxidationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose importManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glucose metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionISS:BHF-UCL
Positive regulation of mesenchymal cell proliferationIEA:Ensembl
Regulation of lipid metabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Response to glucoseISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, cytosol

Takatani, T., Shirakawa, J., Shibue, K., Gupta, M. K., Kim, H., Lu, S., ... & Kulkarni, R. N. (2021). Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. Journal of Biological Chemistry, 296.

Ochiai, T., Sano, T., Nagayama, T., Kubota, N., Kadowaki, T., Wakabayashi, T., & Iwatsubo, T. (2021). Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiology of Disease, 159, 105510.

Neff, A. M., Yu, J., Taylor, R. N., Bagchi, I. C., & Bagchi, M. K. (2020). Insulin signaling via progesterone-regulated insulin receptor substrate 2 is critical for human uterine decidualization. Endocrinology, 161(1), bqz021.

Villar-Lorenzo, A., Rada, P., Rey, E., Marañón, P., Arroba, A. I., Santamaria, B., ... & Gonzalez-Rodriguez, A. (2019). Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury. Disease Models & Mechanisms, 12(7), dmm038810.

Iglesias-Osma, M. C., Blanco, E. J., Carretero-Hernandez, M., Catalano-Iniesta, L., Sanchez-Robledo, V., Garcia-Barrado, M. J., ... & Carretero, J. (2019). The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland. Scientific reports, 9(1), 5673.

Piper, A. J., Clark, J. L., Mercado-Matos, J., Matthew-Onabanjo, A. N., Hsieh, C. C., Akalin, A., & Shaw, L. M. (2019). Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC). PLoS One, 14(8), e0220567.

Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Kahn, C. R., & Emanuelli, B. (2018). Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. Cellular signalling, 47, 1-15.

Mercado-Matos, J., Janusis, J., Zhu, S., Chen, S. S., & Shaw, L. M. (2018). Identification of a novel invasion-promoting region in insulin receptor substrate 2. Molecular and Cellular Biology, 38(14), e00590-17.

Turaihi, A. H., Bakker, W., Van Hinsbergh, V. W., Serné, E. H., Smulders, Y. M., Niessen, H. W., & Eringa, E. C. (2018). Insulin receptor substrate 2 controls insulin-mediated vasoreactivity and perivascular adipose tissue function in muscle. Frontiers in physiology, 9, 245.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IRS2 ELISA Kit (CAT#: V2LY-0626-LY207)

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Human IRS2 ELISA Kit (CAT#: V2LY-0626-LY207)

Isotype control

For research use only. Not intended for any clinical use.

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