KAT14

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.

Full Name

Lysine Acetyltransferase 14

Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Biological Process

Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of cell divisionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of tubulin deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal

Cellular Location

Nucleus; Cytoplasm. Mainly nuclear.