KDM3A

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Full Name
Lysine Demethylase 3A
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Biological Process
Androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to leukemia inhibitory factorIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Formaldehyde biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 dimethylationIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K9 methylationIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of stem cell differentiationIEA:Ensembl
Regulation of stem cell population maintenanceIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spermatid nucleus elongationIEA:Ensembl
Cellular Location
Cytoplasm; Nucleus. Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
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Anti-KDM3A antibodies

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Mouse Anti-KDM3A Recombinant Antibody (CBYJL-032) (CBMAB-L0062-YJ)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-032
Application*: WB, E, IC, IF
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBYJL-031) (CBMAB-L0061-YJ)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-031
Application*: WB, E, IH, IC, IF, P
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT2766) (V2LY-0625-LY610)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2766
Application*: IC, F
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT3449) (V2LY-0625-LY609)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3449
Application*: F
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT799) (V2LY-0625-LY3264)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT799
Application*: WB, IF, IC, E
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT800) (V2LY-0625-LY3263)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT800
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT3747) (V2LY-0625-LY2500)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3747
Application*: WB, IH
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBT2987) (V2LY-0625-LY2499)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2987
Application*: WB, IC
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBYCL-133) (CBMAB-L0034-YC)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-133
Application*: WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (14F8) (CBMAB-K0676-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 14F8
Application*: WB, IP, E, P, F, CI
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (M80810) (CBMAB-K0683-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M80810
Application*: WB, IF, E
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (LEP-02) (CBMAB-K0682-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LEP-02
Application*: E, IC, IF, IH, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (2-00E-01) (CBMAB-K0680-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2-00E-01
Application*: E, WB, IC
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (2-00E-001) (CBMAB-K0679-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2-00E-001
Application*: IA, IF, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (20) (CBMAB-K0678-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 20
Application*: WB, IF
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (13B438) (CBMAB-K0675-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B438
Application*: E, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (1-00E-12) (CBMAB-K0673-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-00E-12
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (1-00E-012) (CBMAB-K0672-LY)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-00E-012
Application*: IA, P, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (C-6) (CBMAB-0302-WJ)

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Target: KDM3A
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: C-6
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (2E1) (CBMAB-0140-WJ)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E1
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (1E12) (CBMAB-0094-WJ)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E12
Application*: IH, WB
Datasheet SDS

Mouse Anti-KDM3A Recombinant Antibody (CBLXK-002) (CBMAB-2207CQ)

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Target: KDM3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBLXK-002
Application*: WB, IP, IC, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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