KLK14

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined. [provided by RefSeq]

Full Name

kallikrein-related peptidase 14

Function

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.

Biological Process

Epidermis morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
FertilizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Seminal clot liquefactionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted, extracellular space

PTM

Proteolytic cleavage of the activation peptide produces the active enzyme.