Mouse Klk14 ELISA Kit (V2LY-0626-LY5787)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.021 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
27.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
kallikrein-related peptidase 14
Function
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
Biological Process
Epidermis morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
FertilizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Seminal clot liquefactionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted, extracellular space
PTM
Proteolytic cleavage of the activation peptide produces the active enzyme.

Kryza, T., Bock, N., Lovell, S., Rockstroh, A., Lehman, M. L., Lesner, A., ... & Clements, J. A. (2020). The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. Molecular oncology, 14(1), 105-128.

Gouin, O., Barbieux, C., Leturcq, F., Des Claustres, M. B., Petrova, E., & Hovnanian, A. (2020). Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation, and IL-36 signature. Journal of Investigative Dermatology, 140(6), 1184-1194.

Falkowski, K., Bielecka, E., Thøgersen, I. B., Bocheńska, O., Płaza, K., Kalińska, M., ... & Kantyka, T. (2020). Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis. International Journal of Molecular Sciences, 21(12), 4383.

Ulbricht, D., Tindall, C. A., Oertwig, K., Hanke, S., Sträter, N., & Heiker, J. T. (2018). Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin. Biological Chemistry, 399(9), 1079-1084.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KLK14 Recombinant Antibody (337903) (CAT#: CBMAB-K1227-LY)

Isotype control

For research use only. Not intended for any clinical use.

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