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Mouse Anti-KLK14 Recombinant Antibody (337903) (CBMAB-K1227-LY)

This product is antibody recognizes KLK14. The antibody 337903 immunoassay techniques such as: IP, Neutralization.
See all KLK14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
337903
Antibody Isotype
IgG1
Application
IP, Neutralization

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 14 Gln19-Met248
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalos
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kallikrein-related peptidase 14
Introduction
This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Entrez Gene ID
43847
UniProt ID
Q9P0G3
Alternative Names
Kallikrein Related Peptidase 14; Kallikrein-Like Protein 6; KLK-L6; Kallikrein 14; Kallikrein-14; EC 3.4.21.-; EC 3.4.21; KLKL6; HK14;
Function
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
Biological Process
Epidermis morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
FertilizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Seminal clot liquefactionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted, extracellular space
PTM
Proteolytic cleavage of the activation peptide produces the active enzyme.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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