KLRC3

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Full Name
killer cell lectin-like receptor subfamily C, member 3
Function
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIBA:GO_Central
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-70
Helical: 71-93
Extracellular: 94-240
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Anti-KLRC3 antibodies

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Mouse Anti-KLRC3 Recombinant Antibody (CBWJN-1118) (CBMAB-N0897-WJ)

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Target: KLRC3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1118
Application*: WB
Datasheet SDS

Rat Anti-KLRC3 Recombinant Antibody (20d5) (CBMAB-N0049-WJ)

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Target: KLRC3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 20d5
Application*: F
Datasheet SDS

Rabbit Anti-KLRC3 Recombinant Antibody (CBLY1-128) (CBMAB-K1405-LY)

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Target: KLRC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-128
Application*: WB
Datasheet SDS

Mouse Anti-KLRC3 Recombinant Antibody (3D5) (CBMAB-K1406-LY)

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Target: KLRC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D5
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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