KRT19 (Concentrate)

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Full Name

Keratin 19

Function

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Biological Process

Cell differentiation involved in embryonic placenta development Source: Ensembl
Cornification Source: Reactome
Keratinization Source: Reactome
Notch signaling pathway Source: Ensembl
Response to estrogen Source: UniProtKB
Sarcomere organization Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Intermediate filament; Terminal web; Cytosol; Extracellular exosome; Apicolateral plasma membrane; Dystrophin-associated glycoprotein complex; Plasma membrane; Sarcolemma; Cell periphery; Costamere; Z disc