LAIR1
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq]
Full Name
LAIR1
Function
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 22-165
Helical: 166-186
Cytoplasmic: 187-287
Helical: 166-186
Cytoplasmic: 187-287
PTM
Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.
N-glycosylated.
N-glycosylated.
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Anti-LAIR1 antibodies
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CompareTarget: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb364
Application*: FC, FuncS, Immuno assays, IP, WB
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B2
Application*: WB, E
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G4
Application*: E, WB
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-133
Tag: His Tag
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-133
Tag: hFc Tag
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-133
Tag: hFc Tag
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-165
Tag: His Tag
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-165
Tag: hFc Tag
Target: LAIR1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-165
Tag: His & AVI Tag
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2379
Application*: F
Target: LAIR1
Specificity: Human
Target: LAIR1
Specificity: Human
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4109
Application*: E, WB, F, P
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2316
Application*: F
Target: LAIR1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0850
Application*: F
Target: LAIR1
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0207
Application*: F
Target: LAIR1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2417
Application*: F
Target: LAIR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2416
Application*: E
Target: LAIR1
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 113
Application*: WB, F
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1066
Application*: IP, WB
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKTA255
Application*: F
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: lc12
Application*: WB, F, E
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7H26
Application*: F
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1063
Application*: E, WB
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1062
Application*: E, F, WB
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4j59
Application*: F
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1061
Application*: E, IP, WB
Target: LAIR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1059
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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