Sign in or Register   Sign in or Register
  |  

Mouse Anti-LAIR1 Recombinant Antibody (CBYJL-1066) (CBMAB-L0499-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1). The antibody can be used for immunoassay techniques, such as IP, WB.
See all LAIR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1066
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LAIR1
Introduction
LAIR1 is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. Gene of LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. An important paralog of this gene is LAIR2.
Entrez Gene ID
UniProt ID
Alternative Names
CD305; LAIR-1
Function
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 22-165
Helical: 166-186
Cytoplasmic: 187-287
PTM
Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.
N-glycosylated.

Lovewell, R. R., Hong, J., Kundu, S., Fielder, C. M., Hu, Q., Kim, K. W., ... & Kim, T. K. (2023). LAIR-1 agonism as a therapy for acute myeloid leukemia. Journal of Clinical Investigation, 133(22), e169519.

Son, M. (2022). Understanding the contextual functions of C1q and LAIR-1 and their applications. Experimental & Molecular Medicine, 54(5), 567-572.

Helou, D. G., Shafiei-Jahani, P., Hurrell, B. P., Painter, J. D., Quach, C., Howard, E., & Akbari, O. (2022). LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. Journal of Allergy and Clinical Immunology, 149(1), 223-236.

Horn, L. A., Chariou, P. L., Gameiro, S. R., Qin, H., Iida, M., Fousek, K., ... & Palena, C. (2022). Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication. The Journal of clinical investigation, 132(8).

Peng, D. H., Rodriguez, B. L., Diao, L., Chen, L., Wang, J., Byers, L. A., ... & Gibbons, D. L. (2020). Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nature communications, 11(1), 4520.

Liu, Y., Ma, L., Shangguan, F., Zhao, X., Wang, W., Gao, Z., ... & Cao, Q. (2020). LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway. Aging (Albany NY), 12(16), 16142.

Guo, N., Zhang, K., Gao, X., Lv, M., Luan, J., Hu, Z., ... & Gou, X. (2020). Role and mechanism of LAIR-1 in the development of autoimmune diseases, tumors, and malaria: a review. Current Research in Translational Medicine, 68(3), 119-124.

Kumawat, K., Geerdink, R. J., Hennus, M. P., Roda, M. A., Van Ark, I., Leusink-Muis, T., ... & Meyaard, L. (2019). LAIR-1 limits neutrophilic airway inflammation. Frontiers in immunology, 10, 842.

Wu, X., Zhang, L., Zhou, J., Liu, L., Fu, Q., Fu, A., ... & Xue, J. (2019). Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma. Current problems in cancer, 43(1), 18-26.

Jin, J., Wang, Y., Ma, Q., Wang, N., Guo, W., Jin, B., ... & Chen, L. (2018). LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro. Cellular Immunology, 331, 78-84.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-LAIR1 Recombinant Antibody (CBYJL-1066)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare