Mouse Anti-LAIR1 Recombinant Antibody (CBWJC-2316) (CBMAB-C3222WJ)

Name: Mouse Anti-LAIR1 Recombinant Antibody (CBWJC-2316)
SKU: CBMAB-C3222WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2316

Application

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LAIR1

Introduction

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

3903

UniProt ID

Q6GTX8

Alternative Names

CD305; LAIR-1

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 22-165
Helical: 166-186
Cytoplasmic: 187-287

PTM

Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.
N-glycosylated.

Lovewell, R. R., Hong, J., Kundu, S., Fielder, C. M., Hu, Q., Kim, K. W., ... & Kim, T. K. (2023). LAIR-1 agonism as a therapy for acute myeloid leukemia. Journal of Clinical Investigation, 133(22), e169519.

Son, M. (2022). Understanding the contextual functions of C1q and LAIR-1 and their applications. Experimental & Molecular Medicine, 54(5), 567-572.

Helou, D. G., Shafiei-Jahani, P., Hurrell, B. P., Painter, J. D., Quach, C., Howard, E., & Akbari, O. (2022). LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. Journal of Allergy and Clinical Immunology, 149(1), 223-236.

Horn, L. A., Chariou, P. L., Gameiro, S. R., Qin, H., Iida, M., Fousek, K., ... & Palena, C. (2022). Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication. The Journal of clinical investigation, 132(8).

Peng, D. H., Rodriguez, B. L., Diao, L., Chen, L., Wang, J., Byers, L. A., ... & Gibbons, D. L. (2020). Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nature communications, 11(1), 4520.

Liu, Y., Ma, L., Shangguan, F., Zhao, X., Wang, W., Gao, Z., ... & Cao, Q. (2020). LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway. Aging (Albany NY), 12(16), 16142.

Guo, N., Zhang, K., Gao, X., Lv, M., Luan, J., Hu, Z., ... & Gou, X. (2020). Role and mechanism of LAIR-1 in the development of autoimmune diseases, tumors, and malaria: a review. Current Research in Translational Medicine, 68(3), 119-124.

Kumawat, K., Geerdink, R. J., Hennus, M. P., Roda, M. A., Van Ark, I., Leusink-Muis, T., ... & Meyaard, L. (2019). LAIR-1 limits neutrophilic airway inflammation. Frontiers in immunology, 10, 842.

Wu, X., Zhang, L., Zhou, J., Liu, L., Fu, Q., Fu, A., ... & Xue, J. (2019). Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma. Current problems in cancer, 43(1), 18-26.

Jin, J., Wang, Y., Ma, Q., Wang, N., Guo, W., Jin, B., ... & Chen, L. (2018). LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro. Cellular Immunology, 331, 78-84.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

LAIR1 Matched Antibody Pair (678) (CAT#: APMAB-678LY)

LAIR1 Matched Antibody Pair (679) (CAT#: APMAB-679LY)

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Isotype control

For research use only. Not intended for any clinical use.

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