LARP1

Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to LARP1 include translation initiation factor binding. An important paralog of LARP1 is LARP1B. LARP1 is a RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5cap in an MTOR-dependent manner and associates with mRNAs containing a 5 terminal oligopyrimidine (5TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV).

La ribonucleoprotein domain family, member 1

RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122).
Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136).
The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136).
When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797).
Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136).
Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543).
Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797).
Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714).
Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).
(Microbial infection) Positively regulates the replication of dengue virus (DENV).

Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to rapamycinManual Assertion Based On ExperimentIMP:UniProtKB
mRNA stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of translationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of macroautophagyManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of translationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translational initiationManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Posttranscriptional regulation of gene expressionManual Assertion Based On ExperimentIDA:FlyBase
Response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Translational initiationManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm
Cytoplasmic granule
Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.

Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.