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LDLRAP1

LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder a
Full Name
low density lipoprotein receptor adaptor protein 1
Function
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
Biological Process
Amyloid precursor protein metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to cytokine stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cholesterol homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Cholesterol metabolic process1 PublicationNAS:UniProtKB
Cholesterol transport1 PublicationNAS:UniProtKB
Low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cholesterol metabolic process1 PublicationIC:BHF-UCL
Positive regulation of low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of receptor-mediated endocytosis involved in cholesterol transportManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Receptor internalizationManual Assertion Based On ExperimentIMP:BHF-UCL
Receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:BHF-UCL
Receptor-mediated endocytosis involved in cholesterol transportManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of protein bindingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cytoplasm
Involvement in disease
Hypercholesterolemia, familial, 4 (FHCL4):
A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL4 inheritance is autosomal recessive.

Anti-LDLRAP1 antibodies

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Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: E-10
Application*: WB, IP, IF, E
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1383
Application*: E, IF, IH, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F3
Application*: F, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1384
Application*: F, IF, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B10
Application*: F, IH, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G4-D5
Application*: E, WB, IH, IF
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G5
Application*: F, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A12
Application*: F, IF, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A5
Application*: WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7E11
Application*: F, IF, P, WB
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7G2
Application*: F
Target: LDLRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H10
Application*: F, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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