LEF1

LEF1 is a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer.

Lymphoid enhancer binding factor 1

Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090).
Participates in the Wnt signaling pathway (By similarity).
Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity).
PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540).
Regulates T-cell receptor alpha enhancer function (PubMed:19653274).
Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity).
May play a role in hair cell differentiation and follicle morphogenesis (By similarity).
Isoform 1
Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Isoform 3
Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling.
Isoform 5
Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.

Anatomical structure regressionIEA:Ensembl
Apoptotic process involved in blood vessel morphogenesisIEA:Ensembl
B cell proliferationIEA:Ensembl
BMP signaling pathwayIEA:Ensembl
Branching involved in blood vessel morphogenesisIEA:Ensembl
Canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cell chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cytokine stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to interleukin-4Manual Assertion Based On ExperimentIDA:UniProtKB
Chorio-allantoic fusionIEA:Ensembl
Dentate gyrus developmentIEA:Ensembl
Embryonic limb morphogenesisIEA:Ensembl
Epithelial to mesenchymal transitionISS:BHF-UCL
Face morphogenesisIEA:Ensembl
Forebrain neuroblast divisionIEA:Ensembl
Forebrain radial glial cell differentiationIEA:Ensembl
Formation of radial glial scaffoldsIEA:Ensembl
Histone H3 acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Histone H3-K56 acetylationIEA:Ensembl
Histone H4 acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland developmentIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic process in bone marrow cellManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell-cell adhesionIDA:UniProtKB
Negative regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-4 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-5 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of striated muscle tissue developmentIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Odontogenesis of dentin-containing toothIEA:Ensembl
Osteoblast differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Paraxial mesoderm formationIEA:Ensembl
Positive regulation by host of viral transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell cycle processIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell proliferation in bone marrowManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell-cell adhesionIDA:UniProtKB
Positive regulation of chondrocyte proliferationIEA:Ensembl
Positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gamma-delta T cell differentiationISS:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of granulocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of Wnt signaling pathwayIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Secondary palate developmentISS:BHF-UCL
Sensory perception of tasteIEA:Ensembl
SomitogenesisIEA:Ensembl
Sprouting angiogenesisIEA:Ensembl
T cell receptor V(D)J recombinationIEA:Ensembl
T-helper 1 cell differentiationISS:UniProtKB
Tongue developmentIEA:Ensembl
Trachea gland developmentIEA:Ensembl

Nucleus
Found in nuclear bodies upon PIASG binding.

Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.