LHX5

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq]

LIM homeobox 5

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Cell proliferation in forebrainIEA:Ensembl
Cerebellar Purkinje cell differentiationIEA:Ensembl
Cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferationIEA:Ensembl
Forebrain neuron differentiationIEA:Ensembl
Hippocampus developmentIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord association neuron differentiationIEA:Ensembl

Nucleus