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Mouse Anti-LHX5 Recombinant Antibody (CBYJL-1627) (CBMAB-L1485-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1627
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
LHX5 (NP_071758, 136aa -235aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 136-235

Target

Full Name
LIM homeobox 5
Introduction
LHX5 is a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. LHX5 may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX1. It plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.
Entrez Gene ID
64211
UniProt ID
Q9H2C1
Function
Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.
Biological Process
Cell proliferation in forebrainIEA:Ensembl
Cerebellar Purkinje cell differentiationIEA:Ensembl
Cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferationIEA:Ensembl
Forebrain neuron differentiationIEA:Ensembl
Hippocampus developmentIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord association neuron differentiationIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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