LSM5

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
Full Name
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Biological Process
mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Response to bacteriumIEA:Ensembl
Cellular Location
Nucleus
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Anti-LSM5 antibodies

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Mouse Anti-LSM5 Recombinant Antibody (CBYCL-506) (CBMAB-L0407-YC)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCL-506
Application*: WB
Datasheet SDS

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2084) (CBMAB-L2224-YJ)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-2084
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-LSM5 Recombinant Antibody (AT25F8) (CBMAB-L2223-YJ)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AT25F8
Application*: E, WB, F, IC, IF
Datasheet SDS

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2083) (CBMAB-L2222-YJ)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2083
Application*: WB
Datasheet SDS

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2082) (CBMAB-L2221-YJ)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-2082
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-LSM5 Recombinant Antibody (2525C1a) (CBMAB-L2220-YJ)

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Target: LSM5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2525C1a
Application*: DB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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