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LSM5

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.

Full Name

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Response to bacteriumIEA:Ensembl

Cellular Location

Nucleus

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Anti-LSM5 antibodies

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Mouse Anti-LSM5 Recombinant Antibody (CBYCL-506) (CBMAB-L0407-YC)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYCL-506

Application*: WB

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2084) (CBMAB-L2224-YJ)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJL-2084

Application*: WB, IP, IF, E

Mouse Anti-LSM5 Recombinant Antibody (AT25F8) (CBMAB-L2223-YJ)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: AT25F8

Application*: E, WB, F, IC, IF

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2083) (CBMAB-L2222-YJ)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2083

Application*: WB

Mouse Anti-LSM5 Recombinant Antibody (CBYJL-2082) (CBMAB-L2221-YJ)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-2082

Application*: WB, F, E, IC, IF

Mouse Anti-LSM5 Recombinant Antibody (2525C1a) (CBMAB-L2220-YJ)

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Target: LSM5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2525C1a

Application*: DB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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