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Mouse Anti-LSM5 Recombinant Antibody (2525C1a) (CBMAB-L2220-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lsm5 Homolog U6 Small Nuclear Rna And Mrna Degradation Associated (LSM5). The antibody can be used for immunoassay techniques, such as Dot.
See all LSM5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2525C1a
Antibody Isotype
IgG2b
Application
Dot

Basic Information

Immunogen
LSM5 antibody was raised in mouse using recombinant Human Lsm5 Homolog, U6 Small Nuclear Rna Associated (S. Cerevisiae) (Lsm5).
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Introduction
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. It plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro.
Entrez Gene ID
23658
UniProt ID
Q9Y4Y9
Alternative Names
YER146W; U6 snRNA-associated Sm-like protein LSm5; LSM5 U6 small nuclear RNA and mRNA degradation associated; LSM5 homolog, U6 small nuclear RNA associated
Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Biological Process
mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Response to bacteriumIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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