LST1
LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been observed for this gene.
Full Name
Leukocyte Specific Transcript 1
Function
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Biological Process
Anatomical structure morphogenesis1 PublicationNAS:UniProtKB
Cell morphogenesisIEA:InterPro
Dendrite developmentManual Assertion Based On ExperimentIDA:UniProtKB
Immune response2 PublicationsNAS:UniProtKB
Negative regulation of lymphocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell shapeIEA:UniProtKB-KW
Cell morphogenesisIEA:InterPro
Dendrite developmentManual Assertion Based On ExperimentIDA:UniProtKB
Immune response2 PublicationsNAS:UniProtKB
Negative regulation of lymphocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell shapeIEA:UniProtKB-KW
Cellular Location
Membrane
Golgi apparatus membrane
Endomembrane system
Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Golgi apparatus membrane
Endomembrane system
Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Topology
Helical: 8-28
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Anti-LST1 antibodies
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Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-517
Application*: IC, P, IP, WB
Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-516
Application*: WB, P, IF, IC, IP
Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: LST1/02
Application*: WB, IC, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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