LST1

LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been observed for this gene.
Full Name
Leukocyte Specific Transcript 1
Function
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Biological Process
Anatomical structure morphogenesis1 PublicationNAS:UniProtKB
Cell morphogenesisIEA:InterPro
Dendrite developmentManual Assertion Based On ExperimentIDA:UniProtKB
Immune response2 PublicationsNAS:UniProtKB
Negative regulation of lymphocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell shapeIEA:UniProtKB-KW
Cellular Location
Membrane
Golgi apparatus membrane
Endomembrane system
Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Topology
Helical: 8-28
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Anti-LST1 antibodies

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Mouse Anti-LST1 Recombinant Antibody (CBYCL-517) (CBMAB-L0418-YC)

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Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-517
Application*: IC, P, IP, WB
Datasheet SDS

Mouse Anti-LST1 Recombinant Antibody (CBYCL-516) (CBMAB-L0417-YC)

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Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-516
Application*: WB, P, IF, IC, IP
Datasheet SDS

Mouse Anti-LST1 Recombinant Antibody (LST1/02) (CBMAB-L2243-YJ)

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Target: LST1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: LST1/02
Application*: WB, IC, IF
Datasheet SDS

Human LST1 ELISA Kit (V2LY-0626-LY2759)

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Target: LST1
Sensitivity: 0.0023 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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