LST1

LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been observed for this gene.

Full Name

Leukocyte Specific Transcript 1

Function

Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.

Biological Process

Anatomical structure morphogenesis1 PublicationNAS:UniProtKB
Cell morphogenesisIEA:InterPro
Dendrite developmentManual Assertion Based On ExperimentIDA:UniProtKB
Immune response2 PublicationsNAS:UniProtKB
Negative regulation of lymphocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell shapeIEA:UniProtKB-KW

Cellular Location

Membrane
Golgi apparatus membrane
Endomembrane system
Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.

Topology

Helical: 8-28

Anti-LST1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-LST1 Recombinant Antibody (CBYCL-517) (CBMAB-L0418-YC)

Datasheet

SDS

Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-517

Application*: IC, P, IP, WB

Mouse Anti-LST1 Recombinant Antibody (CBYCL-516) (CBMAB-L0417-YC)

Datasheet

SDS

Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-516

Application*: WB, P, IF, IC, IP

Mouse Anti-LST1 Recombinant Antibody (LST1/02) (CBMAB-L2243-YJ)

Datasheet

SDS

Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: LST1/02

Application*: WB, IC, IF

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)