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LST1

LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been observed for this gene.

Full Name

Leukocyte Specific Transcript 1

Function

Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.

Biological Process

Anatomical structure morphogenesis1 PublicationNAS:UniProtKB
Cell morphogenesisIEA:InterPro
Dendrite developmentManual Assertion Based On ExperimentIDA:UniProtKB
Immune response2 PublicationsNAS:UniProtKB
Negative regulation of lymphocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell shapeIEA:UniProtKB-KW

Cellular Location

Membrane
Golgi apparatus membrane
Endomembrane system
Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.

Topology

Helical: 8-28

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Anti-LST1 antibodies

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Mouse Anti-LST1 Recombinant Antibody (CBYCL-517) (CBMAB-L0418-YC)

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Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-517

Application*: IC, P, IP, WB

Mouse Anti-LST1 Recombinant Antibody (CBYCL-516) (CBMAB-L0417-YC)

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Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-516

Application*: WB, P, IF, IC, IP

Mouse Anti-LST1 Recombinant Antibody (LST1/02) (CBMAB-L2243-YJ)

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Target: LST1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: LST1/02

Application*: WB, IC, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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