MAP3K21

MAP3K21 (Mitogen-Activated Protein Kinase Kinase Kinase 21) is a Protein Coding gene. An important paralog of this gene is MAP3K9.

Full Name

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21

Function

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Biological Process

Protein autophosphorylationISS:UniProtKB
Protein phosphorylationISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

PTM

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.

Anti-MAP3K21 antibodies

Mouse Anti-MAP3K21 Recombinant Antibody (CBFYM-1524) (CBMAB-M1687-FY)

Datasheet

SDS

Target: MAP3K21

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYM-1524

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)