MAP3K21

MAP3K21 (Mitogen-Activated Protein Kinase Kinase Kinase 21) is a Protein Coding gene. An important paralog of this gene is MAP3K9.

Full Name

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21

Function

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Biological Process

Protein autophosphorylationISS:UniProtKB
Protein phosphorylationISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

PTM

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.

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Target: MAP3K21

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 114-420

Tag: GST Tag

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Target: MAP3K21

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYM-1524

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

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