MAPK15

MAPK15 (Mitogen-Activated Protein Kinase 15) is a Protein Coding gene. Among its related pathways are Jak-Stat Signaling Pathway (sino) and NF-kB (NFkB) Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK7.

Full Name

MITOGEN-ACTIVATED PROTEIN KINASE 15

Function

Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054).
Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227).
Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280).
Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899).
Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093).
Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054).
Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414).
In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526).
Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity).
Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846).
During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity).
Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Dopamine uptakeManual Assertion Based On ExperimentIDA:UniProtKB
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIMP:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of metaphase/anaphase transition of meiosis IIEA:Ensembl
Positive regulation of spindle assemblyIEA:Ensembl
Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomere cappingManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to ciliary transition zoneManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of COPII vesicle coatingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, cilium basal body
Cell junction, tight junction
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasmic vesicle, autophagosome
Golgi apparatus
Nucleus
Cytoplasm
Cytoplasm, cytoskeleton, spindle
Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936).
Translocates to the nucleus upon activation (PubMed:20638370).
At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity).

PTM

Autophosphorylated on Thr-175 and Tyr-177; activates the enzyme.
Ubiquitinated (PubMed:19166846).
Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).