MAPK4

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq]
Full Name
mitogen-activated protein kinase 4
Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Biological Process
Cell cycleIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Translocates to the cytoplasm following interaction with MAPKAPK5.
PTM
Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
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Anti-MAPK4 antibodies

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Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYM-1628) (CBMAB-M1795-FY)

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Target: MAPK4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYM-1628
Application*: E, WB
Datasheet SDS

Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYM-1627) (CBMAB-M1794-FY)

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Target: MAPK4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1627
Application*: IC, WB
Datasheet SDS

Mouse Anti-MAPK4 (AA 42-151) Recombinant Antibody (CBFYM-1626) (CBMAB-M1793-FY)

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Target: MAPK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1626
Application*: E, IF
Datasheet SDS

Mouse Anti-MAPK4 Recombinant Antibody (CBFYM-1625) (CBMAB-M1792-FY)

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Target: MAPK4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1625
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-MAPK4 Recombinant Antibody (CBFYE-1537) (CBMAB-E2178-FY)

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Target: MAPK4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1537
Application*: WB, IH, IF
Datasheet SDS

Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYE-1536) (CBMAB-E2177-FY)

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Target: MAPK4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYE-1536
Application*: WB, IC
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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