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MAPK4

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq]

Full Name

mitogen-activated protein kinase 4

Function

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).

Biological Process

Cell cycleIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus
Translocates to the cytoplasm following interaction with MAPKAPK5.

PTM

Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.

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Anti-MAPK4 antibodies

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Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYM-1628) (CBMAB-M1795-FY)

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Target: MAPK4

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBFYM-1628

Application*: E, WB

Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYM-1627) (CBMAB-M1794-FY)

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Target: MAPK4

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1627

Application*: IC, WB

Mouse Anti-MAPK4 (AA 42-151) Recombinant Antibody (CBFYM-1626) (CBMAB-M1793-FY)

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Target: MAPK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-1626

Application*: E, IF

Mouse Anti-MAPK4 Recombinant Antibody (CBFYM-1625) (CBMAB-M1792-FY)

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Target: MAPK4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1625

Application*: IF, P, WB

Mouse Anti-MAPK4 Recombinant Antibody (CBFYE-1537) (CBMAB-E2178-FY)

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Target: MAPK4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1537

Application*: WB, IH, IF

Rat Anti-MAPK4 (AA 1-126) Recombinant Antibody (CBFYE-1536) (CBMAB-E2177-FY)

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Target: MAPK4

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBFYE-1536

Application*: WB, IC

Human Recombinant MAPK4 protein, GST Tag (V2LY-0526-LY3949)

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Target: MAPK4

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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